教授

博士生導師

生物科學

首都師范大學生命科學學院

馬力耕，男，1965年出生。教授，博士生導師。1987畢業于河北師范大學生物學系，獲學士學位；1990畢業于河北師范大學生物學系植物生理學專業，獲碩士學位；1997 畢業于中國農業大學生物學院生物化學專業，獲博士學位。

論文情況

論文標題為：《MicroRNAs and their targets from Arabidopsis to rice: half conserved and half diverged》，None

論文標題為：《The SNW Domain of SKIP Is Required for Its Integration into the Spliceosome and Its Interaction with the Paf1 Complex in Arabidopsis.》，Abstract SKIP is a conserved protein from yeasts to plants and humans. In plant cells, SKIP is a bifunctional regulator that works in the nucleus as a splicing factor by integrating into the spliceos...

論文標題為：《SKIP Confers Osmotic Tolerance during Salt Stress by Controlling Alternative Gene Splicing in Arabidopsis.》，Abstract Deciphering the mechanisms underlying plant responses to abiotic stress is key for improving plant stress resistance. Much is known about the regulation of gene expression in response to sal...

論文標題為：《The ATP-Binding Cassette Transporter ABCB19 Regulates Postembryonic Organ Separation in Arabidopsis》，The phytohormone auxin plays a critical role in plant development, including embryogenesis, organogenesis, tropism, apical dominance and in cell growth, division, and expansion. In these processes, th...

論文標題為：《USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing》，Post-translational histone modifications play important roles in regulating chromatin structure and function. Histone H2B ubiquitination and deubiquitination have been implicated in transcriptional re...

論文標題為：《A Companion Cell–Dominant and Developmentally Regulated H3K4 Demethylase Controls Flowering Time in Arabidopsis via the Repression of FLC Expression》，Flowering time relies on the integration of intrinsic developmental cues and environmental signals. FLC and its downstream target FT are key players in the floral transition in Arabidopsis. Here, we c...

論文標題為：《Overexpression of a histone H3K4 demethylase, JMJ15, accelerates flowering time in Arabidopsis》，The methylation of histone 3 lysine 4 (H3K4) is essential for gene activation. Flowering Locus C (FLC), an important flowering repressor, quantitatively regulates flowering time in Arabidopsis and its...

論文標題為：《SKIP Is a Component of the Spliceosome Linking Alternative Splicing and the Circadian Clock in Arabidopsis》，Circadian clocks generate endogenous rhythms in most organisms from cyanobacteria to humans and facilitate entrainment to environmental diurnal cycles, thus conferring a fitness advantage. Both transc...

論文標題為：《Overexpression of AtBMI1C, a Polycomb Group Protein Gene, Accelerates Flowering in Arabidopsis》，Polycomb group protein (PcG)-mediated gene silencing is emerging as an essential developmental regulatory mechanism in eukaryotic organisms. PcGs inactivate or maintain the silenced state of their tar...

論文標題為：《Conservation and divergence of the histone H2B monoubiquitination pathway from yeast to humans and plants》，Histone ubiquitination plays a critical role in the regulation of transcription, and histone H2B monoubiquitination (H2Bub1) is mainly associated with transcriptional activation. Recent studies in yea...

論文標題為：《Characterization of the genome expression trends in the heading-stage panicle of six rice lineages》，a b s t r a c t a r t i c l e i n f o To study how changes in gene regulation shape phenotypic variations in rice, we performed a comparative analysis of genome expression in the heading-stage panicle...

論文標題為：《Histone H2B Monoubiquitination in the Chromatin of FLOWERING LOCUS C Regulates Flowering Time in Arabidopsis》，Ubiquitination is one of many known histone modifications that regulate gene expression. Here, we examine the Arabidopsis thaliana homologs of the yeast E2 and E3 enzymes responsible for H2B monoubiqu...

項目情況

項目標題為：《植物基因組層面的可變剪切研究》，項目類型為：國家級項目;其他項目;2013年植物基因組學國家重點實驗室開放課題

項目標題為：《細胞信息》，項目類型為：國家杰出青年科學基金

項目標題為：《細胞外鈣調素對基因表達調控研究》，項目類型為：面上項目

項目標題為：《細胞外鈣調素對花粉萌發調控作用的信號轉導機理研究》，項目類型為：青年科學基金項目

項目標題為：《基因可變剪接參與擬南芥生態型間雜交不親合調控研究》，項目類型為：面上項目

項目標題為：《植物響應鹽堿脅迫的組蛋白修飾和基因轉錄調控機制》，項目類型為：國家級項目;國家973計劃 ;民口973

教育經歷

1987年：河北師范大學生物學系學士學位

1990年：河北師范大學生物學系碩士學位

1997年：中國農業大學生物學院博士學位

工作主要經歷

2011.12- 今 首都師范大學生命科學學院教授、博士研究生導師

2010.1 - 2011.12河北師范大學生命科學學院教授、博士研究生導師

2005.1 - 2010.1 北京生命科學研究所研究員、博士研究生導師

2000.8 - 2004.12美國耶魯大學分子、細胞和發育生物學系博士后

1996.6 - 2000.8 河北師范大學生物學系教授（1998年起博士研究生導師）

1990.7 - 1996.6 河北師范大學生物學系助教、講師

國家自然科學獎二等獎（排名第三）

國家杰出青年基金獲得者

全國百篇優秀博士論文提名獎指導教師

河北省自然科學一等獎（排名第二）

教育部科技進步二等獎（排名第二）

教育部霍英東教育基金會高校青年教師研究三等獎

《利用DNA微陣列芯片研究擬南芥光調控發育過程》入選2002年度“中國高等學校十大科技進展”（論文第一作者，獲獎排名第三）

中國植物生理學會優秀論文一等獎（排名第一）

北京市中關村高端領軍人才

河北省省管優秀專家

河北省有突出貢獻的中青年專家

發表的論文被SCI收錄超過50篇，被SCI引用總次數超過5000次，其中單篇論文最高引用近400次（Ma et al., Plant Cell 2001），發表的主要論文有：

1.    Wang Z, Li J, Chen S, Heng Y, Chen Z, Yang J, Zhou K, Pei J, He H*, Deng XW*, and Ma LG*. Poaceae-specific MS1 encodes a phospholipid-binding protein for male fertility in bread wheat. PNAS, 2017, in press（*通訊作者）

 2.    Li J, Wang Z, Hu Y, Cao Y and Ma LG*. Polycomb Group Proteins RING1A and RING1B Regulate the Vegetative Phase Transition in Arabidopsis. Front. Plant Sci. 2017, 8: 867. doi: 10.3389/fpls.2017.00867.（*通訊作者）

 3.    Feng, J., Ma, LG*. A Method for Characterizing Embryogenesis in Arabidopsis. Journal of Visualized Experiments, 2017, e55969, doi:10.3791/55969 . （*通訊作者）

 4.    Shang X, Cao Y and Ma LG*. Alternative Splicing in Plant Genes: A Means of Regulating the Environmental Fitness of Plants. Int. J. Mol. Sci. 2017, 18, 432; doi:10.3390/ijms18020432（*通訊作者）

 5.    Feng J, Li R, Ma S, Wu C, Li Y, Cao Y, Ma LG*. Protein N-terminal acetylation is required for embryogenesis in Arabidopsis. Journal of Experimental Botany, 2016,  67 : 4779–4789. （*通訊作者）

 6.    Feng J, Ma LG*. NatA is required for suspensor development in Arabidopsis. Plant Signaling & Behavior, 2016 11:e1231293（*通訊作者）

 7.     Li Y, Xia C, Feng J, Yang D, Wu F, Cao Y, Li L, Ma LG*. The SNW Domain of SKIP Is Required for Its Integration into the Spliceosome and Its Interaction with the Paf1 Complex in Arabidopsis. Molecular Plant. 2016, 9, 1040–1050. （*通訊作者）

 8.    Cao Y, Wen L, Wang Z, Ma LG*. SKIP Interacts with the Paf1 Complex to Regulate Flowering via the Activation of FLC Transcription in Arabidopsis. Molecular Plant, 2015, 8, 1816–1819. （*通訊作者）

 9.     Feng J, Li J, Gao Z, Lu Y, Yu J, Zheng Q, Yan S, Zhang W, He H, Ma LG*, Zhu Z*. SKIP Confers Osmotic Tolerance During Salt Stress by Controlling Alternative Gene Splicing in Arabidopsis. Molecular Plant, 2015, 8,1038–1052. （*通訊作者）

 10.     Ning YQ, Ma ZY, Huang HW, Mo H, Zhao T, Lin Li, Cai T, Chen S, Ma LG and He XJ. Two novel NAC transcription factors regulate gene expression and flowering time by associating with the histone demethylase JMJ14. Nucleic Acids Research, 2015, 43:1469-1484.

 11.     Yu Y, Wang J, Zhang Z, Quan R, Zhang H, Deng XW, Ma LG*, Huang R*. Ethylene promotes hypocotyl growth and HY5 degradation by enhancing the movement of COP1 to the nucleus in the light. PLoS Genetics, 2013, 9: e1004025.doi:10.1371/journal.pgen. 1004025. （*通訊作者）

 12.    Wang J, Yu Y, Zhang Z, Quan R, Zhang H, Ma LG, Deng XW, Huang R. Arabidopsis CSN5B interacts with VTC1 and modulates ascorbic acid synthesis. Plant Cell, 2013, 25:625-36. doi: 10.1105/tpc.112.106880 

 13.    Zhang Z, Jones A, Joo HY, Zhou D, Cao Y, Chen S, Erdjument-Bromage H, Renfrow M, He H, Temps P,.Townes TM, Giles KE, Ma LG, and Wang H. USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. 2013, Genes & Development, 27:1581–1595.

 14.    Zhao H., Liu L, Mo H, Qian L, Cao Y, Cui S, Li  X, Ma LG*.The ATP-binding cassette transporter ABCB19 regulates postembryonic organ separation in Arabidopsis. PLoS ONE, 2013, 8(4): e60809. doi:10.1371/journal. pone. 0060809. （*通訊作者）

 15.    Wang X, Wu F, Xie Q, Wang H, Wang Y, Yue Y, Gahura O, Ma  S, Liu L, Cao Y, Jiao Y, Puta F, McClung CR, Xu X, and Ma LG*. SKIP is a component of the spliceosome linking alternative splicing and the circadian clock in Arabidopsis. Plant Cell, 2012, 24: 3278–3295. （*通訊作者）

 16.    Yang HC, Cao Y, Han ZF, Mo HX, Fan D, Li H, Liu L, Yue YL, She C, Chai JJ, and Ma Ma LG*. A companion cell-dominant and developmentally-regulated H3K4 demethylase controls flowering time in Arabidopsis via the repression of FLC expression. PLoS Genetics, 2012, 8:e1002664. （*通訊作者）

 17.    Fan  D, Dai Y, Wang X, Wang Z, He H, Yang H, Cao Y, Deng XW, and Ma LG*.  IBM1, a JmjC domain-containing histone demethylase, is involved in the regulation of RNA-directed DNA methylation through the epigenetic control of RDR2 and DCL3 expression in Arabidopsis. Nucleic Acids Research, 2012, 40:8905-8916. （*通訊作者）

 18.    Zhao H, Wang X, Zhu D, Cui S, and Ma LG*. A single amino acid substitution in a IIIF bHLH transcription factor AtMYC1 leads to trichome and root hair patterning defects by abolishing its interaction with partner proteins in Arabidopsis. Journal of Biological Chemistry, 2012, 287:14109-14121. （*通訊作者）

 19.    Yang HC, Mo HX, Fan D, Cao Y, Cui SJ, and Ma LG*. Overexpression of a histone H3K4 demethylase, JMJ15, accelerated flowering time in Arabidopsis. Plant Cell Reports, 2012, 31:1297-1308. （*通訊作者）

 20.    Zhao H, Li X, and Ma LG*. Basic helix-loop-helix transcription factors and epidermal cell fate determination in Arabidopsis. Plant Signaling & Behavior, 2012, 7:1-5.（*通訊作者）

 21.    Wang X, Ma LG*. Unraveling the circadian clock in Arabidopsis. Plant Signaling & Behavior, 2012, 8(2): pii: e23014. （*通訊作者）

 22.    Cao Y and Ma LG*. Conservation and divergence of the histone H2B monoubiquitination pathway from yeast to humans and plants. Frontier Biology, 2011, 6:109-117. （*通訊作者）

 23.    Li W, Wang Z, Li J, Yang H, Cui S, Wang X, Ma LG*. Overexpression of AtBMI1C, a polycomb group protein gene, accelerates flowering in Arabidopsis. PLoS ONE 2011, 6: e21364. doi:10.1371/ journal.pone. 0021364（*通訊作者）

 24.    Lu SX, Liu H, Knowles SM, Li J, Ma LG, Tobin EM and Lin C. A role for protein kinase CK2 alpha subunits in the Arabidopsis circadian clock. Plant Physiology 2011, 157:1537-1545.

 25.    Ma LG. MicroRNAs and their targets from rice to Arabidopsis : half conserved and half diverged (invited comments). Frontier Biology, 2010, 5 :3-4.

 26.    Jiao YL, Tausta SL , Gandotra N , Sun N, Liu T, Clay NK, Ceserani T, Chen MQ, Ma LG, Holford M, Zhang HY , Zhao HY, Deng XW, Nelson T. A transcriptome atlas of rice cell types uncovers cellular, functional and developmental hierarchies. Nature Genetics, 2009, 41:258-263.

 27.    Cao Y, Dai Y, Cui SJ, Ma LG*. Histone H2B monoubiquitination is required for histone H3K4 methylation of FLC/MAFs chromatin and flowering time control in Arabidopsis. Plant Cell, 2008，20:2586-602. （*通訊作者）

 28.    Wu Y, Zhu Z, Ma LG, Chen M. The preferential retention of starch synthesis genes reveals the impact of whole-genome duplication on grass evolution. Mol. Biol. Evol., 2008, 25:1003-1006. doi: 10.1093/molbev/msn052

 29.  Wang XX, Ma LG*. Polycomb-group (Pc-G) proteins control seed development in Arabidopsis (Invited review). Journal of Integrative Plant Biology, 2007, 49: 52-59. （*通訊作者）

 30.    Qin G, Gu H, Ma LG, Peng Y, Deng XW, Chen Z, Qu LJ. Disruption of phytoene desaturase gene results in albino and dwarf phenotypes in Arabidopsis by impairing chlorophyll, carotenoid, and gibberellin biosynthesis. Cell Research, 2007, 17:471-482.

 31.   Jiao Y*, Ma LG*, Strickland E， Deng XW. Conservation and Divergence of Light-Regulated Genome Expression Patterns during Seedling Development in Rice and Arabidopsis. Plant Cell, 2005，17:3239-3256 (*并列第一作者).

 32.     Ma LG, Chen C, Liu X, Jiao Y, Su N, Li L, Wang X, Cao M, Sun N, Zhang X, Bao J, Li J, Pedersen S, Bolund L, Zhao H, Yuan L, Wong GKS, Wang J, Deng XW, and Wang J. An analysis of transcriptional regulation of the rice genome and its comparison to Arabidopsis. Genome Research，2005, 15：1274-1283.

 33.    Ma LG, Sun N, Liu X, Jiao Y, Zhao H, Deng XW. Organ-specific genome expression atlas during Arabidopsis development. 2005, Plant Physiology,  138:80-91.

 34.    Shen YP, Feng SH, Ma LG, Lin RC, Qu LJ, Chen ZL, Wang HY, Deng XW. Arabidopsis FHY1 protein stability is regulated by light via phytochrome a and 26S proteasome. Plant Physiology, 2005, 139:1234-124.

35.    Feng S*, Ma LG*, Wang X, Xie D, Dinesh-Kumar S. P., Wei N, and Deng XW. The COP9 Signalosome Physically Interacts with SCFCOI1 and Modulates Jasmonate Responses. Plant Cell, 2003, 15:1083-1094 (*并列第一作者).

 36.    Ma LG, Zhao H, Deng XW. Analysis of the mutational effects of the COP/DET/FUS loci on genome expression profiles reveals their overlapping yet not identical roles in regulating Arabidopsis seedling development. Development, 2003, 130: 969-981.

 37.    Wu P, Ma LG, Hou XL, Wang MY, Wu YR, Liu FY, Deng XW Phosphate starvation triggers distinct alterations of genome expression in Arabidopsis roots and leaves. Plant Physiology, 2003, 1321260-1271.

 38.    Ma LG, Gao Y, Qu LJ, Chen ZL, Li JM, Zhao H, Deng XW. Genomic evidence for COP1 as a repressor of light-regulated gene expression and development in Arabidopsis. Plant Cell, 2002，14: 2383-2398.

 39.    Wang H*, Ma LG*, Habashi J, Li JM, Zhao H, Deng XW. Analysis of far-red light-regulated genome expression profiles of phytochrome A pathway mutants in Arabidopsis. Plant Journal, 2002, 32:723-734. (*并列第一作者).

 40.    Holm M, Ma LG, Qu LJ, Deng XW. Two interacting bZIP proteins are direct targets of COP1-mediated control of light-dependent gene expression in Arabidopsis. Genes & Development, 2002, 16: 1247-1259.

 41.    Ma LG, Li JM, Qu LJ, Hager J, Chen ZL, Zhao H, Deng XW. Light control of Arabidopsis development entails coordinated regulation of genome expression and cellular pathways. Plant Cell, 2001, 13: 2589-2607.

 42.  Wang H, Ma LG, Li JM, Zhao H, Deng XW. Direction interaction of Arabidopsis cryptochromes with COP1 in light control development. Science, 2001, 294:154-158.

 43.    Ma LG, Xu X, Cui S, Sun D. The presence of a heterotrimeric G protein and its role in signal transduction of extracellular calmodulin in pollen germination and tube growth. Plant Cell, 1999 11:1351–1363.